internal radiation therapy in treating non-small cell lung cancer. Mediastinal nodal sterilization (MNS) after induction chemoradiotherapy (CRT) can serve as an intermediate marker for efficacy. We show that results from CAPP-Seq and GRP are highly concordant, and the combination of these methods allows for more comprehensive monitoring of ctDNA by profiling a wide spectrum of tumor-specific markers. Our approach may be clinically useful not only in LMS but also in other tumor types that lack recurrent genomic alterations. In this study, we explored a mechanism through which these benefits may be obtained. To obtain uniformly optimal plans, individual anatomic optimization would be needed. MAYER AND TIMMERMAN." We used DNA microarrays, representing approximately 18,000 genes, to examine the temporal program of gene expression following treatment of the human prostate cancer cell line LNCaP with a synthetic androgen.We observed statistically significant changes in levels of transcripts of more than 500 genes. primary site (place where it started) to the lungs (metastases) treated with stereotactic The addition of etanidazole at clinically achievable tumor concentrations produces a large increase in the expected level of tumor cell killing from the large radiation doses used in SABR.The presence of tumor hypoxia is a major negative factor in limiting the curability of tumors by SABR at radiation doses that are tolerable to surrounding normal tissues. The frequencies of these mutations vary between populations but are less well characterized in the Vietnamese population. regimens and to see how well they work in treating patients with stage I non-small cell lung Roose, J. P., Diehn, M., Tomlinson, M. G., Lin, J., Alizadeh, A. Within the colon, the Hedgehog protein signal does not act directly on the epithelium itself, but on underlying stromal cells to induce expression of IL-10, an immune-modulatory cytokine long known to suppress inflammatory intestinal damage. Notably, subsets of CSCs in some human and murine breast tumours contain lower ROS levels than corresponding non-tumorigenic cells (NTCs). by killing the cells, by stopping them from dividing, or by stopping them from spreading. Wang, S. Y., Zhang, B. M., Wakelee, H. A., Koontz, M. Z., Pan, M., Diehn, M., Kunder, C. A., Neal, J. W. FLT-PET-CT for the Detection of Disease Recurrence After Stereotactic Ablative Radiotherapy or Hyperfractionation for Thoracic Malignancy: A Prospective Pilot Study. Substantial progress has been made regarding molecular determinants of response to targeted agents in advanced lung cancer, and recent findings have revealed subsets of patients with driver mutations that respond rapidly to selective inhibitors. Median follow-up was 38.7 months. Azad, T. D., Chaudhuri, A. Auf den Rapper Kontra K, bürgerlicher Name Maximilian Diehn, bin ich durch Maria (fiktiver Name) gekommen. All plans were recalculated for the same beam specifications using MC and EPL, respectively. Nair, V. S., Li, A., Stehr, H., Chabon, J., Chaudhuri, A., Zhou, L., Naemi, H., Ayers, K., Ramsey, M., Bedi, H. S., Van Wert, R., Sung, A. W., Lui, N., Backhus, L., Berry, M., Shrager, J. events and conferences; acting as key opinion leaders and experts We evaluated the outcomes and imaging prognostic factors of HypoRT.We retrospectively reviewed the data from all patients with primary and metastatic intrathoracic tumors treated with HypoRT from 2006 to 2012. We set out to systematically characterize the global gene expression patterns that specify the distinctive characteristics of the various eye compartments.We used DNA microarrays representing approximately 30,000 human genes to analyze gene expression in the cornea, lens, iris, ciliary body, retina, and optic nerve. Because it leverages these diverse training data and our improved machine learning framework, MARIA (area under the curve = 0.89-0.92) outperformed existing methods in validation datasets. We identified cases of NSCLC with METex14 mutations using an institutionally developed or commercial next-generation sequencing assay. The investigators will do this using a variety of molecular analysis tools Extracellular matrix (ECM) remodelling was enriched among genes associated with PCI (p = 0.0003). Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II molecules would be valuable for vaccine development and cancer immunotherapies. Circulating Tumor DNA Measurements As Early Outcome Predictors in Diffuse Large B-Cell Lymphoma. IMRT was associated with similar toxicity risks on multivariate analysis compared with 3D-CRT. View details for PubMedID 31011689, View details for DOI 10.1016/j.adro.2018.11.006, View details for Web of Science ID 000516858500027. We compared the gene-expression profiles between transformed DLBCL and their antecedent FL. All statistical tests for survival were two-sided.The MPI stratified stage I patients into prognostic categories in three microarray and one FFPE qPCR validation cohorts (HR = 2.99, 95% CI = 1.55 to 5.76, P < .001 in stage IA patients of the largest microarray validation cohort; HR = 3.95, 95% CI = 1.24 to 12.64, P = .01 in stage IA of the qPCR cohort). We confirmed that normal fibroblasts transformed to CAF-like cells, following TGF-beta treatment, upregulated HBP genes, including GFPT2, with less change in genes driving glycolysis, pentose phosphate pathway and TCA cycle. Noninvasive Cancer Classification Using Diverse Genomic Features in Circulating Tumor DNA, Esfahani, M., Newman, A. M., Scherer, F., Tibshirani, R., Diehn, M., Alizadeh, A. based on tumor-specific factors. In the meta-testing and validation cohorts, the immune signature significantly stratified patients into high- vs low-risk groups in terms of overall survival across and within subpopulations with stage I, IA, IB, or II disease and remained as an independent prognostic factor in multivariate analyses (hazard ratio range, 1.72 [95% CI, 1.26-2.33; P. To evaluate the prognostic value and molecular basis of a CT-derived pleural contact index (PCI) in early stage non-small cell lung cancer (NSCLC).We retrospectively analysed seven NSCLC cohorts. We also evaluated the following tumor metrics in an exploratory analysis: gross tumor volume (GTV), maximum standardized uptake value (SUVMax), and metabolic tumor volume using a threshold of ≥ 50% of the SUVMax (MTV50%) or the maximum gradient of fluorine-18 fluorodeoxyglucose uptake (MTVEdge). View details for DOI 10.1016/j.prro.2015.05.008, View details for DOI 10.1016/j.ijrobp.2015.07.251, View details for Web of Science ID 000373215301909, View details for DOI 10.1016/j.ijrobp.2015.07.093, View details for Web of Science ID 000373215301755, View details for Web of Science ID 000363830000216, View details for Web of Science ID 000365159900004, View details for DOI 10.1016/j.ijrobp.2015.07.1660, View details for Web of Science ID 000373215301157, View details for DOI 10.1016/j.ijrobp.2015.07.1641, View details for Web of Science ID 000373215301138, View details for DOI 10.1016/j.ijrobp.2015.07.357, View details for Web of Science ID 000373215302039, View details for DOI 10.1016/j.ijrobp.2015.07.1580, View details for Web of Science ID 000373215301078, View details for DOI 10.1016/j.ijrobp.2015.07.1603, View details for Web of Science ID 000373215301101, View details for DOI 10.1016/j.ijrobp.2015.07.1628, View details for Web of Science ID 000373215301125. to guide the radiation therapy, may help doctors deliver higher doses directly to the tumor Scherer, F., Kurtz, D., Green, M., Newman, A. M., Klass, D. M., Zhou, L., Krishnan, R., Liu, C., Glover, C., Ohgami, R. S., Hicks, R. J., Keane, C., Kong, K. A., Faham, M., Hertzberg, M. S., Gandhi, M. K., Advani, R. H., Levy, R., Diehn, M., Alizadeh, A. The purpose of this study is to evaluate the A. Noninvasive Detection of Ibrutinib Resistance in Non-Hodgkin Lymphoma Using Cell-Free DNA. Giving radical-dose image guided radiation therapy to patients with Jiang, D., Turner, B., Song, J., Li, R., Diehn, M., Le, Q., Khatri, P., Koong, A. C. Sinoatrial node toxicity after stereotactic ablative radiation therapy to lung tumors. We report our institutional experience treating patients with MET exon 14 skipping (METex14) mutations, including responses to the MET inhibitors crizotinib and cabozantinib. Of the 15 plans originally planned with NEE, 4 plans were dosimetrically superior with NEE, 2 plans were dosimetrically superior with DIBH, and 9 plans were dosimetrically equivalent.For 10 of 41 plans, planning with 1 respiratory state was superior. Both techniques had superior OS compared with 2D-RT. • PCI can be used to noninvasively identify patients with poor prognosis. Gentles, A. J., Newman, A. M., Liu, C., Bratman, S. V., Feng, W., Kim, D., Nair, V. S., Yue, X., Khuong, A., Hoang, C. D., Diehn, M., West, R. B., Plevritis, S. K., Alizadeh, A. View details for DOI 10.1158/2159-8290.CD-20-0282, View details for DOI 10.1038/s43018-019-0011-0. spread. Disease recurrence within a timeframe of 12 months could be predicted with an accuracy of 81.3-82.7%. Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., Joshua, B., Kaplan, M. J., Wapnir, I., Dirbas, F. M., Somlo, G., Garberoglio, C., Paz, B., Shen, J., Lau, S. K., Quake, S. R., Brown, J. M., Weissman, I. L., Clarke, M. F. Therapeutic Implications of the Cancer Stem Cell Hypothesis, Identification of noninvasive imaging surrogates for brain tumor gene-expression modules. Ross, J. If our findings are validated, exhaled breath analysis may become a useful approach for noninvasive identification of patients at highest risk for developing RP after SABR. high local control and survival using SBRT in stage I NSCLC patients. Stereotactic Ablative Radiotherapy (SABR). from Harvard College and his MD/PhD Fifteen plans were created for treatment with use of natural end exhale (NEE), and 26 plans used deep inspiration breath hold (DIBH). LC of retreated lesions was significantly lower, likely owing to the lower doses used for retreatment. Concentrations of exhaled nitric oxide (eNO), carbon monoxide (eCO), nitrous oxide (eN2O), and carbon dioxide (eCO2) were measured before and immediately after each fraction using real-time, infrared laser spectroscopy. Patients who experienced symptomatic RP had significantly higher non-target lung FDG-PET uptake as measured by mean SUV (p 0.56. 3-year cumulative incidence of LR was 26.8% per patient and 11.9% per lesion. In addition, we identified distinct patterns of clonal evolution distinguishing indolent follicular lymphomas from those that transformed into DLBCL, allowing for potential noninvasive prediction of histological transformation. For more information, please contact laura gable, (650) 736 - 0798. Adherence of D283 medulloblastoma cells to type I collagen matrix in vitro depends on the beta1 subunit of integrin. To develop and clinically evaluate a volumetric imaging technique for assessing intrafraction geometric and dosimetric accuracy of stereotactic ablative radiation therapy (SABR).Twenty patients received SABR for lung tumors using volumetric modulated arc therapy (VMAT). To search for new mast cell products, we used complementary DNA microarrays to analyze gene expression in human umbilical cord blood-derived mast cells stimulated via the high-affinity IgE receptor (Fc(epsilon)RI).One to two hours after Fc(epsilon)RI-dependent stimulation, more than 2,400 genes (about half of which are of unknown function) exhibited 2-200 fold changes in expression. For more information, please contact Katie Brown, 650-723-1423. Stanford University - Cited by 21,266 - Cancer biology - stem cell biology - genomics - biomarkers - circulating tumor DNA Volume expansion of the untreated adjacent lobe(s) was positively correlated with volume reduction of the treated lobe (r(2)=0.47, P Characterization of the variation in gene expression in healthy tissue is an essential foundation for the recognition and interpretation of the changes in these patterns associated with infections and other diseases, and peripheral blood was selected because it is a uniquely accessible tissue in which to examine this variation in patients or healthy volunteers in a clinical setting. Of those, 390, plus 31 references supplied by the Expert Panel, were selected for full-text review. This joint review from the American Society of Clinical Oncology and the College of American Pathologists summarizes current information about clinical ctDNA assays and provides a framework for future research.METHODS: - An Expert Panel conducted a literature review on the use of ctDNA assays for solid tumors, including preanalytical variables, analytical validity, interpretation and reporting, and clinical validity and utility.RESULTS: - The literature search identified 1338 references. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 1. No grade ≥ 3 toxicities developed. Dudley, J., Schroers-Martin, J., Lazzareschi, D., Shi, W., Chen, S., Liao, J., Alizadeh, A., Diehn, M. Comparison of Genomic Driver Oncogenes in Vietnamese Patients With Non-Small-Cell Lung Cancer in the United States and Vietnam. View details for DOI 10.1016/j.ijrobp.2014.06.006 Those kilovolt projections acquired during millivolt beam-on were automatically extracted, and intrafraction CBCT images were reconstructed using the filtered backprojection technique. Giving lapatinib When restricting the analysis to patients with stage III disease (n=32), the same subregion achieved an even higher CI of 0.75 (hazard ratio 3.93, log-rank P=.002) for predicting OS, and a CI of 0.76 (hazard ratio 4.84, log-rank P=.002) for predicting OFP. View details for DOI 10.1016/j.semradonc.2014.12.007, View details for Web of Science ID 000351254100002, View details for Web of Science ID 000356736300007, View details for Web of Science ID 000351254100003.
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